Rna Interference

Interfering Rna Rnai Stage 6. The Risc Complex Rna Induced Silencing Complex Is Linked To A Fragment Of Single Stranded Rna Rna Guide, Breaks Away From The Rna Target Molecule That Has Just Cleaved. It Is Then Free To Cleave Another Molecule Of Specific Rna. Interfering Rna Is A Mean For The Cell To Destroy The Rna Parasites Viruses Rna, Transposons. The Dicer Protein, A Type Iii Ribonuclease, Fixes To The Double Stranded Rna, And Cleaves It Into Fragments Of 21 25 Nucleotides. Then, A Proteic Complex Named Risc For Rna Induced Silencing Complex Fixes To The Whole Dicer Fragment Of Double Stranded Rna. One Of The Rna Strands Is Then Eliminated Passenger Rna, Whereas The Other Rna Guide Remains Linked To The Risc Dicer Complex. By Sequence Complementarity, The Rna Guide Then Fixes To The Specific Rna Molecule Of The Virus Or Transposon. The Latter Is Then Cut By The Endonuclease Activity Of Risc Cleavage Then Destroyed. The Cell Then Eliminates All Foreign Rna. Rna Interference Is Currently Under Study To Turn Off Individual Gene Expression Silencing In The Framework Of The Development Of New Therapies. (Photo By BSIP/UIG Via Getty Images)